Journal
ORAL DISEASES
Volume 21, Issue 5, Pages 667-673Publisher
WILEY
DOI: 10.1111/odi.12334
Keywords
YKL-40; gingival crevicular fluid; periodontitis; diabetes
Categories
Funding
- Japan Society for the Promotion of Science (Tokyo, Japan) [22890126]
- Grants-in-Aid for Scientific Research [15H05054, 22890126, 25253104] Funding Source: KAKEN
Ask authors/readers for more resources
ObjectiveYKL-40 is a chitin-binding glycoprotein, the level of which increases in inflammatory diseases, diabetes mellitus (DM), cardiovascular diseases, and tumors. Gingival crevicular fluid (GCF) contains many proteins and markers of periodontitis. The purpose of this study was to investigate YKL-40 level in GCF from patients with periodontitis and DM and the association between YKL-40 level and chronic periodontitis (CP) or DM. Subjects and MethodsThe subjects were 121 patients with DM, CP, DM and periodontitis (DM-P), and healthy subjects (H). GCF was collected using paper strips after the sites for GCF collection were clinically evaluated for probing depth (PD), gingival index (GI), and bleeding on probing (BOP). YKL-40 in GCF was identified by Western blotting, and its level was determined by ELISA. ResultsYKL-40 was contained in GCF samples from H, DM, CP, and DM-P sites, and its levels (amount and concentration) in CP and DM-P were significantly higher than those in H and DM. GCF YKL-40 level significantly correlated with PD and GI, and its level in BOP-positive sites was significantly higher than that in BOP-negative ones. ConclusionsGCF YKL-40 level was elevated in periodontitis, but not DM. YKL-40 in GCF may be an inflammatory marker for periodontitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available