Journal
JOURNAL OF HEPATOLOGY
Volume 56, Issue 6, Pages 1305-1309Publisher
ELSEVIER
DOI: 10.1016/j.jhep.2012.01.020
Keywords
Liver transplantation; Steroid; Donor pretreatment; Early liver allograft function
Categories
Funding
- Austrian Science Fund [FWF P-18325, FWF P-21436]
- Austrian Academy of Science [OELZELT EST370/04]
- Austrian Science Fund (FWF) [P 21436] Funding Source: researchfish
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Background & Aims: Brain death-associated inflammatory response contributes to increased risk of impaired early liver allograft function, which might be counterbalanced by steroid pretreatment of the organ donor. The aim of this randomized controlled trial was to elucidate whether steroid pretreatment of liver donors improves early liver allograft function, prevents rejection and prolongs survival. Methods: A placebo-controlled blinded randomized clinical trial was performed in three different centers in Austria and Hungary between 2006 and 2008. Ninety deceased organ donors received either 1000 mg of methylprednisolone or placebo 6 h before recovery of organs. The primary end point was the concentration slope of transaminases within the first week. The secondary end point included survival and biopsy-confirmed acute rejection (BCAR) within 3 years after transplantation. Results: Of the 90 randomized donors, 83 recipients were eligible for study. The trajectories of ALT and AST were not different between treatments (p = 0.40 and p = 0.13, respectively). Eight subjects died in the steroid and 13 in the placebo group within 3 years after engraftment (RR = 0.63 95% CI [0.29, 1.36], p = 0.31). Eleven recipients experienced biopsy-confirmed rejection (BCAR) in the steroid and 11 in the placebo group (RR = 1.02 95% CI [0.50, 2.10], p = 1.00). No effect modification could be identified in the predefined strata of donor age, sex, cold ischemic time, and cause of donor death. Conclusions: Steroid pretreatment of organ donors did not improve outcomes after liver transplantation. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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