Journal
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
Volume 21, Issue 5, Pages 301-308Publisher
SPRINGER JAPAN KK
DOI: 10.1002/jhbp.62
Keywords
Cholangiocarcinoma; Liver cancer; Liver fluke; Opisthorchis viverrini; Thailand
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Funding
- Higher Education Research Promotion and Office of the Higher Education Commission, through health cluster (SHeP-GMS), Basic Research Grant, Thailand Research Fund
- Targeted Research Grant, Faculty of Medicine, Khon Kaen University
- Visiting International Professor Program, Faculty of Medicine, Khon Kaen University
- Khon Kaen University Publication Clinic, Research and Technology Transfer Affairs, Khon Kaen University
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Several factors are known to be associated with risk of cholangiocarcinoma (CCA) and infection with the liver flukes, Opisthorchis viverrini and Clonorchis sinensis, has often been singled out as the leading risk factor in east and southeast Asia. In this review, current knowledge of their biology, life cycle, and pathogenesis of O.viverrini, and its role as a carcinogenic parasite are presented. The trends of age-specific incidence of liver cancer in Khon Kaen, northeast Thailand are considered and compared with the prevalence profiles of O.viverrini. Potential impacts of the liver fluke control program particularly by mass drug administration (MDA) and public health education in the past and a recent drop of incidence of CCA are discussed in relation to primary prevention and control of this fatal bile duct cancer.
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