Journal
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
Volume 21, Issue 3, Pages 193-198Publisher
SPRINGER JAPAN KK
DOI: 10.1002/jhbp.16
Keywords
Distal pancreatectomy; Duct-to-mucosa anastomosis; Pancreatic fistula; Pancreaticojejunostomy
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BackgroundA pancreatic fistula is one of the most serious complications in distal pancreatectomy with en bloc celiac axis resection (DP-CAR), because the pancreatic transection is performed on the right side of the portal vein, which results in a large cross-section surface, and because post-pancreatectomy hemorrhage is hard to treat by interventional radiology. Therefore, a procedure to decrease the incidence of postoperative pancreatic fistula is urgently needed. MethodsTwenty-six consecutive patients who underwent DP-CAR between April 2008 and August 2012 were reviewed retrospectively. The first 13 consecutive patients underwent DP-CAR with no anastomosis, and the subsequent 13 consecutive patients were treated with Roux-en-Y pancreaticojejunostomy (PJ) in a duct-to-mucosa fashion. ResultsExtremely high amylase levels (>4000IU/l) of all drainage fluid specimens on postoperative day (POD) 1, 3 and 4 were detected more frequently in cases with no anastomosis (n=7) compared to those with PJ (n=1) (P=0.056). ConclusionThe incidence of grade B/C pancreatic fistulas was 15.4% in cases with isolated Roux-en-Y anastomosis of the pancreatic stump performed in a duct-to-mucosa fashion, and we are currently examining whether this anastomosis method reduces the pancreatic fistula rate in a multicenter, randomized controlled trial for distal pancreatectomy patients (ClinicalTrials.gov NCT01384617).
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