Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 7, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13045-014-0084-2
Keywords
microRNA (miRNA); KRAS; Cancer; Sequence variant; Single nucleotide polymorphism (SNP); KRAS-variant; rs61764370; rs712
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While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation.
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