Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 7, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13045-014-0072-6
Keywords
Immune thrombocytopenia; T cell; Immune tolerance; Pathogenesis
Categories
Funding
- National Natural Science Foundation [81100336, 81070396, 81070411, 81125002, 81370623, 81270578]
- Natural Science Foundation of Shandong Province [ZR2013HQ001]
- Cultivation Fund of the Key Scientific and Technical Innovation Project
- Ministry of Education of China [NO704030]
- Taishan Scholar Foundation
- SRF for ROCS
- SRF for SEM
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Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia. The induction of T cell tolerance is an important mechanism by which the pathogenesis and treatment of immune thrombocytopenia can be studied. Studies regarding the roles of the new inducible costimulator signal transduction pathway, the ubiquitin proteasome pathway, and the nuclear factor kappa B signal transduction pathway in the induction of T cell tolerance can help improve our understanding of immune theory and may provide a new theoretical basis for studying the pathogenesis and treatment of immune thrombocytopenia.
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