Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 5, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1756-8722-5-12
Keywords
ASXL1; Gene mutations; Myeloid diseases
Categories
Funding
- Inserm
- Institut Paoli-Calmettes
- Association pour la Recherche sur le Cancer
- Association Laurette Fugain
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The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.
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