Journal
JOURNAL OF HELMINTHOLOGY
Volume 85, Issue 1, Pages 92-99Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0022149X10000337
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Funding
- National '973' Program of China [2010CB530004]
- National '863' Program of China [2006AA02Z422]
- National Natural Science Foundation of China [30640028]
- Natural Science Foundation of Guangdong Province [8251008901000007]
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Angiostrongylus cantonensis infection causes eosinophilic meningitis in humans. Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. In this study we evaluated the efficacy of the combination of albendazole and baicalein for treating eosinophilic meningitis in BALB/c mice. Therapeutic efficacy included the survival time, body weight, neurological function, leucocyte and eosinophil counts, eotaxin concentration, matrix metalloproteinase-9 (MMP-9) activity, larval recovery and histopathological examination. The results showed that the combination of albendazole and baicalein was more effective than either drug administered singly. Combination therapy increased the survival time, decreased body weight loss, neurological dysfunction, leucocyte response, eotaxin concentration and MMP-9 activity. Our results suggest that the combination of albendazole and baicalein may exhibit synergistic beneficial effects in the treatment of eosinophilic meningitis induced by A. cantonensis.
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