Journal
JOURNAL OF HEART AND LUNG TRANSPLANTATION
Volume 32, Issue 12, Pages 1147-1162Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.healun.2013.08.011
Keywords
heart; antibody mediated rejection; immunohistochemistry; immunofluorescence; intravascular; activated mononuclear cells; complement
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During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved from a relatively obscure concept to a recognized clinical complication in the management of heart transplant patients. Herein we report the consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection. The diagnostic criteria for its morphologic and immunopathologic components are enumerated, illustrated, and described in detail. Numerous challenges and unresolved clinical, immunologic, and pathologic questions remain to which a Working Formulation may facilitate answers. (C) 2013 International Society for Heart and Lung Transplantation. All rights reserved.
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