A regenerative strategy for heart failure in hypoplastic Left heart syndrome: Intracoronary administration of autologous bone marrow-derived progenitor cells

Novel surgical strategies have dramatically improved the initial outcome of newborns with hypoplastic left heart syndrome. However, the single systemic right ventricle remains a major challenge, with limited effectiveness of pharmacologic therapy. The present case documents that the intracoronary administration of autologous bone marrow-derived progenitor cells is technically feasible in a critically ill infant with hypoplastic left heart syndrome and severe heart failure after a hybrid comprehensive stage II procedure. Cell therapy might represent an option before heart transplantation in children with single ventricle physiology presenting with severe heart failure. J Heart Lung Transplant 2010;29:574-577 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved.