Journal
OPTICS LETTERS
Volume 40, Issue 15, Pages 3568-3571Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.40.003568
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Funding
- Singapore Ministry of Health's National Medical Research Council
- Singapore National Research Foundation [NMRC/EDG/1062/2012]
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In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor. (C) 2015 Optical Society of America
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