Journal
JOURNAL OF HEADACHE AND PAIN
Volume 15, Issue -, Pages -Publisher
SPRINGEROPEN
DOI: 10.1186/1129-2377-15-42
Keywords
Serotonin transporter; Trigeminal Neuralgia; Susceptibility; Chinese
Categories
Funding
- Research Project of Shenyang Science and Technology Bureau [F11-262-9-04]
Ask authors/readers for more resources
To investigate the possible association between the serotonin transporter gene (5-HTTLPR) and rs 25531 polymorphism and the susceptibility and the pain severity in Trigeminal Neuralgia patients. A total of 244 TN patients and 280 age and sex matched healthy volunteer were recruited. 5-HTTLPR and rs 25531 genotyping were performed. All patients received the carbamazepine treatment and the treatment response was evaluated at 6 months. The genotype distribution of 5-HTTLPR between TN patients and controls were significantly different. The TN Patients had a higher prevalence of short-short genotype than controls. The short-short genotype carriers are also significantly associated with higher pain severity and poorer carbamazepine treatment response compared to the long-long genotype carriers. In contrast, the rs 25531 polymorphism was not associated with the susceptibility to TN, neither with the pain severity and the treat response to carbamazepine. The 5-HTTLPR polymorphism is associated with the susceptibility to TN and pain severity of TN.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available