Journal
JOURNAL OF HEADACHE AND PAIN
Volume 10, Issue 5, Pages 311-315Publisher
BMC
DOI: 10.1007/s10194-009-0144-0
Keywords
Triptans; Recurrence; Ergotamine
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Recurrence was first recognised as a clinical problem in 1989 with the advent of sumatriptan. The history of recurrence in early sumatriptan randomised clinical trials is described. Recurrence has been ascribed to patient-dependent factors but experience with ergot alkaloids suggested that recurrence can also be treatment-dependent. Possible mechanisms for recurrence are discussed.
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