Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 370, Issue -, Pages 138-146Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhazmat.2018.07.049
Keywords
Pharmaceutical contaminants sulfamethazine and sulfamethoxazole; biodegradation; metabolic products; microalgae; toxicity modeling
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology (MEST) of the South Korean government [2017R1A2B2004143]
- Doosan Yonkang Foundation
- National Research Foundation of Korea [22A20153413355, 21A20130011104] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study investigated the environmental effects of two common emerging contaminants, sulfamethazine (SMZ) and sulfamethoxazole (SMX), and their mixture using a green microalga, Scenedesmus obliquus. The calculated EC50 values of SMZ, SMX, and their mixture (11:1 wt/wt) after 96 h were 1.23, 0.12, and 0.89 mg L-1, respectively. The toxicity of the mixture could be better predicted using a concentration addition model than an independent action model. The risk quotients of SMZ, SMX, and their mixture were > 1 during the experiment, indicating their high potential risks on aquatic microorganisms. Despite their toxicity, S. obliquus exhibited 17.3% and 29.3% removal of 0.1 mg L-1 and 0.2 mg L-1 after 11 days of cultivation. The changes of SMZ and SMX removal were observed when combined, which showed a significantly improved removal of SMZ (up to 3.4 folds) with addition of SMX (0.2 mg L-1). The metabolic pathways of SMZ and SMX were proposed according to mass spectroscopic analysis, which showed six metabolites of SMX and seven intermediates of SMZ, formed as a result of ring cleavage, hydroxylation, methylation, nitrosation, and deamination.
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