Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 194, Issue -, Pages 440-444Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2011.07.113
Keywords
Mitochondria; Quantum dots; Mitochondrial permeability transition; Apoptosis
Categories
Funding
- Chinese 863 Program [2007AA06Z407]
- Chinese 973 Program [2011CB933600]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1030]
- National Natural Science Foundation of China [21077081, 20921062]
- Ph. D. Research Foundation of Wuhan University [046]
- Fundamental Research Funds for the Central Universities [1103005]
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Quantum dots (QDs) hold great promise in many biological applications, with the persistence of safety concerns about the environment and human health. The present work investigated the potential toxicity of CdTe QDs on the function of mitochondria isolated from rat livers by examining mitochondrial respiration, swelling, and lipid peroxidation. We observed that QDs can significantly affect the mitochondrial membrane properties, bioenergetics and induce mitochondrial permeability transition (MPT). These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level. (C) 2011 Elsevier B.V. All rights reserved.
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