Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 180, Issue 1-3, Pages 773-776Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2010.04.041
Keywords
PCBs; Hormesis; Cytotoxicity; Vero cells
Categories
Funding
- Program of Zhejiang Province Bureau of Science and Technology [2007C23037]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0536]
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The effect of polychlorinated biphenyls (PCBs) on Vero cell proliferation was investigated, with the attempts to assess the possible hormetic dose-response and to compare their structure-dependent toxicity. Both PCB congeners revealed low doses stimulation in our experiment. However, significant cytotoxicity was only observed in PCB 52 concentrations larger than 0.1 mu g ml(-1), while there was no significant inhibition in PCB 77-treated cells at concentrations selected. Furthermore, the time-dependent cytotoxic trends were different. The comparison between PCB 52 and PCB 77 indicated that the cytotoxic mechanisms involved in coplanar or non-coplanar PCB congener exposure were different, and this difference might be associated with individual genotoxicity and the release of contact inhibition, respectively. (C) 2010 Elsevier B.V. All rights reserved.
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