Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 181, Issue 1-3, Pages 1175-1178Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhazmat.2010.05.103
Keywords
Carbamazepine; Elimination; Ligninolytic enzymes; Laccase; 1-Hydroxybenzotriazole
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Funding
- Japan Society for the Promotion of Science [20580173]
- Grants-in-Aid for Scientific Research [20580173] Funding Source: KAKEN
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Carbamazepine (CBZP) is used as an antiepileptic drug and is highly persistent. In this study, CBZP was treated with laccase from white rot fungus Trametes versicolor in the presence of a redox mediator 1-hydroxybenzotriazole (HBT). A single treatment with laccase and HBT eliminated CBZP by about 22% after 24 h, and repeated treatments with laccase and HBT, which were added to the reaction mixture every 8 h, helped eliminate about 60% of CBZP after 48 h. This suggests that repeated treatment is effective in eliminating CBZP. Mass spectrometric analyses demonstrated that two degradation products of CBZP, 10,11-dihydro-10,11-epoxycarbarnazepine and 9(10H)-acridone, were formed via repeated treatment with laccase and HBT. (C) 2010 Elsevier B.V. All rights reserved.
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