Comparison of Retinal Nerve Fiber Layer Thickness Values Using Stratus Optical Coherence Tomography and Heidelberg Retina Tomograph-III

Purpose: To evaluate the usefulness Of retinal nerve fiber layer (RNFL) thickness measurements using the Heidelberg Retina Tomograph-III (HRT-III) in normal, ocular hypertensive, a lid glaucomatous eyes and compare the thickness Measurements using HRT-III and Stratus Optical Coherence Tomography-3 (OCT-3). Methods: Sixty-nine normal eyes. 60 eyes ocular hypertensive. and III glaucomatous were included. All participants underwent visual field, HRT-III. and OCT-3 examinations on the same day. Patients were classified into 3 groups according to intraocular pressure and visual field damage. The sensitivity/specificity of RNFL thickness measurements and RNFL thickness classifications using HRT-III and OCT-3 were calculated. The sensitivity/specificity of the height variation contour (HVC) from the HRT-III were calculated. The receiver operating characteristic Curves (ROC) and areas under the ROC were plotted, Agreement was calculated using Bland-Altman method and the K coefficient. Results: The RNFL thickness sensitivity/specificity were 32.4%/ 87%, for the HRT-III and 72.97%/81.15% for the OCT-3 in relation to the glaucoma diagnosis (least specific criteria). The RNFL thickness sensitivities/specificities were lower in early (glaucoma. The areas under the ROC for RNFL measurements were 0.72 using HRT-III, 0.86 with OCT-3 (P = 0.001). and 0.54 for the HVC. I-lie RNFL classification K coefficient was 0.36. Bland-Altman analysis confirmed that the RNFL measurements were not interchangeable. Conclusions: The sensitivity of RNFL damage detection using HRT-III was lower compared with OCT-3. especially in early glaucoma. RNFL thickness agreement between HRT-III and OCT-3 was only fair. HVC was not useful for glaucoma detection.