Journal
JOURNAL OF GLAUCOMA
Volume 17, Issue 2, Pages 147-156Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IJG.0b013e31814b990d
Keywords
glaucoma drug delivery; topical medications
Categories
Funding
- NATIONAL EYE INSTITUTE [R24EY017045, P30EY006360] Funding Source: NIH RePORTER
- NEI NIH HHS [P-30-EY06360, R24-EY017045] Funding Source: Medline
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Topical medications remain the mainstay of glaucoma treatment. This review will aim to cover the pharmacokinetics of topically applied drops, the ocular barriers to drug delivery, and the role of ophthalmic drug formulation in enhancing drug delivery to the target tissue while minimizing side effects and increasing patient compliance. Recent advances in surgical techniques, therapeutic approaches, and material sciences have produced exciting new therapies for ocular diseases. The development of new vehicles and drug formulations that require less patient compliance is also discussed, as are the routes of drug delivery for neuroprotection.
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