Journal
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
Volume 23, Issue 4, Pages 228-242Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988710383572
Keywords
genetics; neurodegeneration; Parkinson disease
Categories
Funding
- Department of Veterans Affairs [1I01BX000531]
- National Institutes of Health [P50 NS062684, R01 NS065070, T32 AG000258]
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Parkinson disease (PD) is the second most common neurodegenerative disorder. In most instances, PD is thought to result from a complex interaction between multiple genetic and environmental factors, though rare monogenic forms of the disease do exist. Mutations in 6 genes (SNCA, LRRK2, PRKN, DJ1, PINK1, and ATP13A2) have conclusively been shown to cause familial parkinsonism. In addition, common variation in 3 genes (MAPT, LRRK2, and SNCA) and loss-of-function mutations in GBA have been well-validated as susceptibility factors for PD. The function of these genes and their contribution to PD pathogenesis remain to be fully elucidated. The prevalence, incidence, clinical manifestations, and genetic components of PD are discussed in this review.
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