Journal
JOURNAL OF GENETICS AND GENOMICS
Volume 40, Issue 2, Pages 67-73Publisher
SCIENCE PRESS
DOI: 10.1016/j.jgg.2012.07.014
Keywords
Pig; Transgene; Gene targeting; Human disease model
Funding
- National Basic Research Program of China (973 Program) [2011CBA01000, 2011CB944203]
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Genetically modified animal models are important for understanding the pathogenesis of human disease and developing therapeutic strategies. Although genetically modified mice have been widely used to model human diseases, some of these mouse models do not replicate important disease symptoms or pathology. Pigs are more similar to humans than mice in anatomy, physiology, and genome. Thus, pigs are considered to be better animal models to mimic some human diseases. This review describes genetically modified pigs that have been used to model various diseases including neurological, cardiovascular, and diabetic disorders. We also discuss the development in gene modification technology that can facilitate the generation of transgenic pig models for human diseases.
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