Journal
JOURNAL OF GENERAL VIROLOGY
Volume 93, Issue -, Pages 1984-1990Publisher
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.042853-0
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Funding
- Emil Aaltonen Foundation
- Helsinki Biomedical Graduate School, HUS/EVO TYH [2000839]
- Academy of Finland
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Sindbis virus (SINV) is an arthropod-borne alphavirus, which causes rash-arthritis, particularly in Finland. SINV is transmitted by mosquitoes in Finland but thus far no virus has been isolated from mosquitoes. In this study, we report the isolation of the first SINV strain from mosquitoes in Finland and its full-length protein-coding sequence. We furthermore describe the full-length coding sequence of six SINV strains previously isolated from humans in Finland and from a mosquito in Russia. The strain isolated from mosquitoes (Ilomantsi-2005M) was very closely related to all the other Northern European SINV strains. We found 9 aa positions, of which five in the nsP3 protein C terminus, to be distinctive signatures for the Northern European strains that may be associated with vector or host species adaptation. Phylogenetic analyses further indicate that SINV has a local circulation in endemic regions in Northern Europe and no novel strains are frequently being introduced.
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