Journal
JOURNAL OF GENERAL VIROLOGY
Volume 93, Issue -, Pages 2063-2075Publisher
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.042978-0
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Funding
- Netherlands Scientific Organization (NWO Vidi grant) [917.76.330]
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Pro-inflammatory cytokines are important mediators in immune responses against invading pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18 are processed by caspase-1. Caspase-1 is activated through autocleavage, but how this is regulated remained elusive for a long time. In 2002, an intracellular multimeric complex was discovered that facilitated caspase-1 cleavage and was termed 'inflammasome'. To date, different inflammasomes have been described, which recognize a variety of ligands and pathogens. In this review, we discuss the role of inflammasomes in sensing viral infection as well as the evasion strategies that viruses developed to circumvent inflammasome-dependent effects.
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