Journal
JOURNAL OF GENERAL VIROLOGY
Volume 92, Issue -, Pages 2394-2398Publisher
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.034322-0
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Funding
- Cancer Research UK [C7934]
- MRC [G0800154, G0400408]
- Government of Ghana Education Trust
- University of Warwick
- MRC [G0800154, G0400408, G0401584] Funding Source: UKRI
- Medical Research Council [G0401584, G0400408, G0800154] Funding Source: researchfish
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Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type 1 interferon (IFN) induction. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of vIRF-2 activity. The biological significance of vIRF-2 inhibition of ISGF-3 was demonstrated by vIRF-2-mediated rescue of the replication of the IFN-sensitive virus encephalomyocarditis virus. This study provides both a mechanism and evidence for KSHV vIRF-2-mediated suppression of the consequences of type 1 IFN-induced signalling.
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