Journal
JOURNAL OF GENERAL VIROLOGY
Volume 91, Issue -, Pages 1693-1697Publisher
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.019851-0
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Funding
- 'Geconcerteerde Onderzoeksacties - Vlaamse Gemeenschap' (GOA) [00/12]
- EU
- MRC [G0401586] Funding Source: UKRI
- Medical Research Council [G0401586] Funding Source: researchfish
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Chimeric yellow fever virus 17D (YFV-17D) and dengue virus type 2 (DENV2) carrying the surface proteins of Modoc virus (MODV), a not-known-vector (NKV) flavivirus, replicated efficiently in mammalian (Vero-B) and mosquito (C6/36) cells, whereas MODV failed to replicate in mosquito cells. Transfection of C6/36 cells with MODV RNA did not result in virus replication; however, transfection of these mosquito cells with YFV-17D or DENV2 RNA did. The inability of NKV viruses (such as MODV) to infect and replicate in arthropod cells is thus not determined by the viral envelope, but by a post-entry event.
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