Journal
JOURNAL OF GENERAL VIROLOGY
Volume 90, Issue -, Pages 2575-2580Publisher
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.011494-0
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Funding
- Biotechnology Biological Sciences Research Council UK
- Biology of Neurodegenerative Disease [BBS/B/03688, CPA1741]
- Chinese Government
- Biotechnology and Biological Sciences Research Council [BBS/B/03688] Funding Source: researchfish
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Prion diseases in ruminants, especially sheep scrapie, cannot be fully explained by PRNP genetics, suggesting the influence of a second modulator gene. The SPRN gene is a good candidate for this role. The SPRN gene encodes the shadoo protein (Sho) which has homology to the PRNP gene encoding prion protein (PrP). Murine Sho has a similar neuroprotective activity to PrP and SPRN gene variants are associated with human prion disease susceptibility. SPRN gene sequences were obtained from 14 species in the orders Artiodactyla and Rodentia. We report here the sequences of more than 20 different Sho proteins that have arisen due to single amino acid substitutions and amino acid deletions or insertions. All Sho sequences contained an alanine-rich sequence homologous to a hydrophobic region with amyloidogenic characteristics in PrP. In contrast with PrP, the Sho sequence showed variability in the number of alanine residues.
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