Journal
JOURNAL OF GENERAL VIROLOGY
Volume 90, Issue -, Pages 2375-2380Publisher
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.013250-0
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Funding
- Medical Research Council
- Wellcome Trust
- MRC [MC_U130184136, G0700142, G0900740] Funding Source: UKRI
- Medical Research Council [G0700142, G0900740, MC_U130184136] Funding Source: researchfish
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The genomes of commonly used variants of human cytomegalovirus (HCMV) strains Towne and AD169 each contain a substantial mutation in which a region (U-L/b') at the right end of the long unique region has been replaced by an inverted duplication of a region from the left end of the genome. Using high-throughput technology, we have sequenced HCMV strain Towne (ATCC VR-977) and confirmed the presence of two variants, one exhibiting the replacement in UL/b' and the other intact in this region. Both variants are mutated in genes RL13, UL1, UL40, UL130, US1 and US9. We have also sequenced a novel AD169 variant (varUC) that is intact in UL/b' except for a small deletion that affects genes UL144, UL142, UL141 and UL140. Like other AD169 variants, varUC is mutated in genes RL5A, RL13, UL36 and UL131A. A subpopulation of varUC contains an additional deletion affecting genes IRS1, US1 and US2.
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