Journal
JOURNAL OF GENERAL VIROLOGY
Volume 89, Issue -, Pages 1309-1313Publisher
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/vir.0.83662-0
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RNA-dependent RNA polymerases, the key enzymes in replication of RNA viruses, have a low fidelity; thus, these viruses replicate as a swarm of mutants termed viral quasispecies. Constant generation of new mutations allows RNA viruses to adapt swiftly to a novel environment through selection of both pre-existing and de novo-generated genetic variants. Here, quasispecies dynamics were studied in vivo in controlled hantavinus transmission from experimentally infected to naive rodents through infested cage bedding. An elementary step of virus microevolution was apparent, as one synonymous mutation (A759G) repeatedly became fixed in the viral RNA quasispecies populations in the recipient animals.
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