Journal
JOURNAL OF GENERAL PHYSIOLOGY
Volume 143, Issue 6, Pages 679-692Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1085/jgp.201311153
Keywords
-
Categories
Funding
- National Institutes of Health National Heart, Lung, and Blood Institute [R37HL076795]
- National Institute of Mental Health [R01MH065531, F31MH088109]
- National Institute of Neurological Disorders and Stroke [R01NS073874]
Ask authors/readers for more resources
Calmodulin regulation (calmodulation) of the family of voltage-gated Ca(V)1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca2+ sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca2+ signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca2+ feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available