Journal
JOURNAL OF GENERAL PHYSIOLOGY
Volume 140, Issue 6, Pages 587-594Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1085/jgp.201210873
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Funding
- National Institutes of Health (NIH) [NIGMS P-01 55876, GM030376, GM062342, GM007183-35]
- Graduate Program in Biophysical Sciences at the University of Chicago (NIH) [T32 EB009412]
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Developing an understanding of the mechanism of voltage-gated ion channels in molecular terms requires knowledge of the structure of the active and resting conformations. Although the active-state conformation is known from x-ray structures, an atomic resolution structure of a voltage-dependent ion channel in the resting state is not currently available. This has motivated various efforts at using computational modeling methods and molecular dynamics (MD) simulations to provide the missing information. A comparison of recent computational results reveals an emerging consensus on voltage-dependent gating from computational modeling and MD simulations. This progress is highlighted in the broad context of preexisting work about voltage-gated channels.
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