Journal
JOURNAL OF GASTROINTESTINAL SURGERY
Volume 13, Issue 11, Pages 2027-2033Publisher
SPRINGER
DOI: 10.1007/s11605-009-0999-z
Keywords
Rectum; Autonomic nervous system; Hypogastric nerve; Pelvic nerve; Sacral nerve stimulation
Categories
Ask authors/readers for more resources
The colon and rectum are regulated by the autonomic nervous system (ANS). Abnormalities of the ANS are associated with diseases of the colon and rectum while its modulation is a putative mechanism for sacral nerve stimulation. The purpose of this study is to establish a rat model elucidating the role of the efferent ANS on rectal motility. Rectal motility following transection or stimulation of parasympathetic pelvic nerves (PN) or sympathetic hypogastric nerves (HGN) was measured with rectal strain gauge transducers and quantified as a motility index (MI). Colonic transit was measured 24 hours after transection by calculating the geometric center (GC) of distribution of Cr-51 Transection of PN and HGN decreased MI to 518 +/- 185 gaEuro cent s (p < 0.05) and increased MI to 5,029 +/- 1,954 gaEuro cent s (p < 0.05), respectively, compared to sham (975 +/- 243 gaEuro cent s). Sectioning of PN and HGN decreased transit with GC = 4.9 +/- 0.2 (p < 0.05) and increased transit with GC = 8.1 +/- 0.7 (p < 0.02), respectively, compared to sham (GC = 5.8 +/- 0.3). Stimulation of PN and HGN increased MI to 831 +/- 157% (p < 0.01) and decreased MI to 251 +/- 24% (p < 0.05), respectively. Rectal motility is significantly altered by sectioning or stimulating either HGN or PN. This model may be useful in studying how sacral nerve stimulation exerts its effects and provide insight into the maladies of colonic motility.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available