Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 28, Issue -, Pages 93-98Publisher
WILEY
DOI: 10.1111/jgh.12243
Keywords
hepatitis C; hepcidin; iron; oxidative stress; reactive oxygen species
Categories
Funding
- Japan Society for the Promotion of Science [23390201]
- Ministry of Health, Labor and Welfare of Japan
- Research Project Grant P2 from Kawasaki Medical School
- Grants-in-Aid for Scientific Research [23390201, 24659377, 25670374] Funding Source: KAKEN
Ask authors/readers for more resources
The liver is the major iron storage organ in the body, and therefore, iron metabolic disorder is sometimes involved in chronic liver diseases. Chronic hepatitis C is one of the liver diseases that show hepatic iron accumulation, even though its level should be recognized to be basically mild to moderate and sometimes within the normal range. The mechanisms underlying hepatic iron accumulation in chronic hepatitis C have not been fully elucidated. Reduction of the hepcidin transcription activity by hepatitis C virus (HCV)-induced reactive oxygen species may in part account for it, but the regulation of hepcidin is very complex and may depend on many variables, including the particular stage of the systemic and/or hepatic inflammatory conditions and the circulating transferrin-bound iron and intracellular iron stores. This might explain the variations in hepatic iron concentrations reported among patients with HCV-related chronic liver disease. However, even mild-to-moderate iron overload in the liver contributes to disease progression and hepatocarcinogenesis in chronic hepatitis C probably by reinforcing the HCV-induced oxidative stress through Fenton reaction. The present review highlights the current concept of hepatic iron overload status in chronic hepatitis C and discusses how iron metabolic disorder develops in this disease and the impact of hepatic iron overload on disease progression and its relevance to hepatocarcinogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available