Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 27, Issue 1, Pages 165-172Publisher
WILEY
DOI: 10.1111/j.1440-1746.2011.06798.x
Keywords
acute liver failure; autoimmune hepatitis; cell therapy; mesenchymal stem cell
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [20591510]
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Background and Aim: Fulminant hepatitis is mainly caused by excessive immune response-mediated liver injury and its definitive therapy is liver transplantation. Mesenchymal stem cells, one of the adult stem cells, have an immunomodulatory effect on immune cells and reside in various tissues. The aim of this study was to investigate a therapeutic effect of adipose tissue-derived mesenchymal stem cells (ASCs) on fulminant hepatitis induced by concanavalin A (ConA).
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