Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 23, Issue -, Pages S31-S36Publisher
WILEY
DOI: 10.1111/j.1440-1746.2007.05281.x
Keywords
Ca2+ toxicity; endoplasmic reticulum; endosome; lysosome; pancreatic cell death; zymogen granule
Categories
Funding
- Medical Research Council [G8801575] Funding Source: Medline
- MRC [G8801575] Funding Source: UKRI
- Medical Research Council [G8801575] Funding Source: researchfish
Ask authors/readers for more resources
Alcohol induces Ca2+-dependent intracellular trypsinogen activation in the apical granular area via non-oxidative metabolites, such as fatty acid ethyl esters and fatty acids. Intracellular trypsinogen activation is a crucial initiating event in the development of acute pancreatitis, but the specific organelle in which this process takes place has been unknown. Recent data demonstrate that the Ca2+-dependent trypsinogen activation occurs in postexocytotic endocytic vacuoles. These vacuoles are acid due to a bafflomycin-sensitive vacuolar H+ ATPase and have a very Ca2+-permeable membrane. Acid endocytic structures, together with lysosomes, zymogen granules and elements of the endoplasmic reticulum, also play an important role in the physiological Ca2+ signal generation that normally regulates enzyme and fluid secretion from the exocrine pancreas.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available