Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 23, Issue -, Pages S112-S118Publisher
WILEY
DOI: 10.1111/j.1440-1746.2007.05274.x
Keywords
alcohol; hepatic stellate cell; innate immunity; liver fibrosis; natural killer cell
Categories
Funding
- Intramural NIH HHS [Z01 AA000369-06] Funding Source: Medline
Ask authors/readers for more resources
The hepatic innate immune system consists of predominant innate immunity, which plays an important role in innate defense against infection and tumor transformation. Emerging evidence suggests that innate immunity also contributes to liver injury, repair, and fibrosis. The present review summarizes the recent findings on the role of innate immunity in liver fibrosis. In general, Kupffer cells stimulate liver fibrosis via production of reactive oxygen species and pro-inflammatory cytokines, whereas natural killer (NK) cells inhibit liver fibrosis by directly killing activated hepatic stellate cells and production of gamma-interferon (IFN-gamma). Complement components, interferons, and Toll-like receptors have also been shown to regulate liver fibrosis. Recent evidence also suggests that modulation of innate immunity by alcohol plays an important role in the pathogenesis of alcoholic liver fibrosis. These include alcohol amplification of the profibrotic effects of Kupffer cells and suppression of the antifibrotic effects of NK/IFN-gamma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available