Journal
JOURNAL OF GASTROENTEROLOGY
Volume 48, Issue 7, Pages 781-797Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00535-012-0712-y
Keywords
Gastric cancer; Cancer stem cell; Biomarker; Signaling pathway; Microenvironment
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Funding
- National Natural Science Foundation of China, China [81160254]
- Grants-in-Aid for Scientific Research [25293093] Funding Source: KAKEN
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Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.
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