Journal
JOURNAL OF FOOD PROTECTION
Volume 72, Issue 2, Pages 325-331Publisher
INT ASSOC FOOD PROTECTION
DOI: 10.4315/0362-028X-72.2.325
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Funding
- Seoul Research and Business Development Program [10816]
- SRC program of the Korea Science and Engineering Foundation [R11-2005-008-02001-0]
- National Research Foundation of Korea [2003-0041387] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The inhibitory effects of green tea polyphenol epigallocatechin gallate (EGCG) on virulence phenotypes and gene expression regulated by quorum sensing (QS) in Escherichia coli O15TH7 were demonstrated at concentrations of 1 to 100 mu g/ml, which are lower than the MIC (539 +/- 22 mu g/ml). At 25 mu g/ml, the growth rate was not affected, but autoinducer 2 concentration, biofilm formation, and swarm motility decreased to 13.2, 11.8, and 50%, respectively. Survival at 5 days of nematodes (Caenorhabditis elegans) that were fed the pathogen without and with EGCG were 47.1 and 76%, respectively. Real-time PCR data indicated decreased transcriptional level in many quorum sensing-regulated virulence genes at 25 mu g/ml. Our results suggest that EGCG at concentrations below its MIC has significant antipathogenic effects against E. coli O157:H7.
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