Journal
JOURNAL OF FOOD AND DRUG ANALYSIS
Volume 22, Issue 1, Pages 18-28Publisher
FOOD & DRUG ADMINSTRATION
DOI: 10.1016/j.jfda.2014.01.002
Keywords
Cell environmentally responsive mechanisms; Controlled-release delivery system; Mesoporous silica nanoparticles; Stimuli-responsive
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Funding
- National Natural Science Foundation of China [NSFC 21001033, 21271044]
- NSF of Fujian [2011J01039]
- Research Foundation for Talented Scholars in Fu Zhou University [022330]
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To develop novel tumor cell microenvironment stimuli-responsive smart controlled-release delivery systems is one of the current common interests of materials science and clinical medicine. Meanwhile, mesoporous silica nanoparticles as a promising drug carrier have become the new area of interest in the field of biomedical application in recent years because of their unique characteristics and abilities to efficiently and specifically entrap cargo molecules. This review describes the more recent developments and achievements of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled-release systems that are able to respond to tumor cell environmental changes, such as pH, glucose, adenosine-5'-triphosphate (ATP), glutathione (GSH), and H2O2. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
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