Journal
JOURNAL OF FOOD AND DRUG ANALYSIS
Volume 22, Issue 4, Pages 500-504Publisher
FOOD & DRUG ADMINSTRATION
DOI: 10.1016/j.jfda.2014.02.001
Keywords
Biological sample; Ion mobility spectrometry (IMS); Tramadol
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Funding
- Islamic Azad University (IAU), Yazd Branch, Yazd, Iran [501100002660]
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In this study, a simple and rapid ion mobility spectrometry (IMS) method has been described for the determination of tramadol. The operating instrumental parameters that could influence IMS were investigated and optimized (temperature; injection: 220 and IMS cell: 190 degrees C, flow rate; carrier: 300 and drift: 600 mL/minute, voltage; corona: 2300 and drift: 7000 V, pulse width: 100 mu s). Under optimum conditions, the calibration curves were linear within two orders of magnitude with R-2 >= 0.998 for the determination of tramadol in human plasma, saliva, serum, and urine samples. The limits of detection and the limits of quantitation were between 0.1 and 0.3 and 0.3 and 1 ng/mL, respectively. The relative standard deviations were between 7.5 and 8.8%. The recovery results (90-103.9%) indicate that the proposed method can be applied for tramadol analysis in different biological samples. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
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