Journal
JOURNAL OF FOOD AND DRUG ANALYSIS
Volume 21, Issue -, Pages S77-S81Publisher
FOOD & DRUG ADMINSTRATION
DOI: 10.1016/j.jfda.2013.09.039
Keywords
Medical effects; Methamphetamine use; Psychiatric effects; Treatment
Categories
Funding
- NIDA NIH HHS [R13 DA035084, P30 DA016383] Funding Source: Medline
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Methamphetamine (MA) is a drug that is widely used in many parts of the world. It has multiple neurobiological impacts on the nervous system; some of which are transitory and some longer lasting. MA activates the reward system of the brain and produces effects that are highly reinforcing, which can lead to abuse and dependence. Routes of administration that produce rapid onset of the drug effects (i.e., smoking and injection) are likely to lead to more rapid addiction and more medical and psychiatric effects. The medical effects of MA use are extensive, and chronic use of MA can produce significant neurological damage as well as damage to cardiovascular, pulmonary, and other organ systems. Both acute and chronic MA use can lead to extreme paranoia, anxiety, and depression, and following discontinuation of MA use, cognitive deficits, and anhedonia can persist for several months. No effective pharmacotherapies have been developed for MA dependence, although this is an area of active research. Several behavioral treatments have been shown to reduce MA use, but better treatments are needed. The research agenda for MA is substantial, with development of effective pharmacotherapies as one of the most important priorities. Copyright (C) 2013, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
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