Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 167, Issue -, Pages 79-83Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2014.05.013
Keywords
Trifluoromethylation; Radical; Ketone; Visible light; Photoredox; Electrophilic
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Funding
- National Basic Research Program of China (973 Program) [2012CB821600]
- National Natural Science Foundation of China [21032006, 21172241]
- Shanghai Science and Technology Commission [11ZR1445700]
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alpha-Trifluoromethyl ketones are important fluorinated intermediates and products in chemical synthesis and medicinal development. Herein, visible light-catalyzed photoredox trifluoromethylation of 1-aryl-2-alkyl substituted alkenes using an electrophilic trifluoromethylating reagent to produce alpha-trifluoromethyl ketones is reported. Two possible pathways involving either a trifluoromethyl radical or a styrene radical cation are proposed and discussed. (C) 2014 Elsevier B.V. All rights reserved.
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