Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 135, Issue -, Pages 91-96Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2011.09.005
Keywords
Polyhydroquinoline; FeF3; One-pot synthesis; Hantzsch condensation
Categories
Ask authors/readers for more resources
A facile and highly efficient one-pot synthesis of polyhydroquinoline derivatives is reported via four-component condensation reaction of aldehydes, beta-keto compounds, active methylene compounds and ammonium acetate in the presence of FeF3 as a catalyst in ethanol at 75-80 degrees C. The method offers several advantages including high yields, short reaction time, simple work-up procedure and catalyst reusability for several runs. The higher catalytic activity of FeF3 ascribed due to its high acidity, thermal stability and water tolerance. The superiority of use of FeF3 to the current process is compared with other Lewis acids, Fe-salts, fluoride sources and insights of the origin of the efficiency are discussed. (C) 2011 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available