Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 133, Issue -, Pages 67-71Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2011.07.025
Keywords
Copper; Silver; Trifluoromethylation, C-C coupling
Categories
Funding
- DFG [436 UKR 113]
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An alternative copper halide-free route to obtain highly reactive trifluoromethylcopper species has been developed via the reaction of silver fluoride and trimethyl(trifluoromethyl)silane followed by a redox transmetallation with elemental copper. The composition of the reactive intermediate was investigated by means of UV/Vis/NIR, ESR, F-19 NMR spectroscopy and ESI mass spectrometry. Trifluoromethylcopper prepared by the oxidative transmetallation route exhibits excellent reactivity and selectivity in substitutions of iodine or bromine bond to aromatic or heterocyclic compounds for trifluoromethyl groups without any additional catalyst. (C) 2011 Elsevier B.V. All rights reserved.
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