Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 132, Issue 10, Pages 804-810Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2011.05.006
Keywords
Cationic gold; Fluorination; Selectfluor; Fluoroketones; Alkynes
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Funding
- National Science Foundation [CHE-0809683]
- CREAM Mass Spectrometry Facility (University of Louisville)
- NSF/EPSCoR [EPS-0447479]
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A library-friendly synthesis of alpha-substituted-alpha-fluoroketones through functionalized hydration of alkynes in one pot under mild conditions is reported. The ready availability of alkynes and organoboronic acids makes this reaction quite attractive. We also studied the key intermediate a fluorinated cationic gold species using in situ NMR spectroscopy and ESI-high resolution mass spectrometry. (C) 2011 Elsevier B.V. All rights reserved.
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