L-Proline catalyzed condensation-cyclization tandem process: Facile and effective synthesis of 3-polyfluoroalkanesulfonyl coumarin

A L-proline catalyzed condensation-cyclization tandem process is reported, which affords the potentially pharmaceutic coumarin derivatives. The mild conditions, simplicity of the purification process and satisfactory yields makes the method a facile and effective way toward the 3-polyfluoroalkanesulfonyl coumarins. (C) 2011 Elsevier B.V. All rights reserved.