Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 132, Issue 1, Pages 35-40Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2010.11.001
Keywords
Fluorinated cationic amphiphilic graft copolymer; DNA; Interaction
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Funding
- Natural Science Foundation of Hubei Province of China
- Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules
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A novel fluorine-containing amphiphilic cationic copolymer P(HFMA-St-MOTAC)-g-PEG was synthesized as a new probe to detect DNA based on the RLS technique. The aggregation of P(HFMA-St-MOTAC)g-PEG on the molecular surface of DNA occurred under pH 4.0-7.0 resulted in an enhanced resonance light-scattering (RLS) peaks at 370 nm, 400 nm, 420 nm and 470 nm. The intensity of resonance light-scattering was found to be proportional to the concentration of DNA. The detection limit was 5.8 mu g L-1. It was found that the P(HFMA-St-MOTAC)-g-PEG has strong interaction with DNA as confirmed by the resonance light scattering (RLS) spectroscopy, UV spectra, IR spectra, and TEM. (c) 2010 Elsevier B.V. All rights reserved.
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