Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 131, Issue 3, Pages 439-445Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2009.11.025
Keywords
Fluorinated amino acids; Fluorinated peptides; Fluorocarbon eluent; Fluorocarbon column; HPLC; Fluorophilicity
Categories
Funding
- NIH [EB 004416]
- Kimmel Foundation
Ask authors/readers for more resources
Chromatographic conditions for the separation of fluorinated amino acids and oligopeptides from their non-fluorinated counterparts were explored. The separation of six pairs of analytes, including both aromatic and aliphatic fluorocarbons, was investigated at various temperatures using both hydrocarbon and fluorocarbon columns and eluents. Our results show that when hydrocarbon eluents are used, fluorocarbon column provides better separation of fluorinated amino acids or oligopeptides from their non-fluorinated counterparts; when fluorocarbon eluents are used, hydrocarbon column provides better separation of fluorinated amino acids or oligopeptides from their non-fluorinated counterparts. These chromatographic behaviors reflect the fluorophilicity possessed by fluorinated amino acids and oligopeptides. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available