A facile and efficient synthesis of beta-amino alcohols using 2,2,2-trifluoroethanol as a metal-free and reusable medium

Trifluoroethanol Was used as a reusable catalyst and medium for the ring opening of epoxides using aliphatic and aromatic amines as nucleophile tinder mild conditions to give the corresponding beta-amino alcohols in high yields and regioselectivity. (C) 2009 Elsevier B.V. All rights reserved.