Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 130, Issue 12, Pages 1178-1182Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2009.09.002
Keywords
Chemical biology; Membrane proteins; Antimicrobial peptides; Anti-diabetic therapeutics
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Funding
- NCI NIH HHS [R01 CA125033, R01 CA125033-01A2] Funding Source: Medline
- NIGMS NIH HHS [R01 GM065500-08, R01 GM065500] Funding Source: Medline
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0821508] Funding Source: National Science Foundation
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Very few molecules with biological origins contain the element fluorine. Nature's inability to incorporate fluorine into biomolecules is related to the low concentration of free fluoride in sea and surface water. However, judicious introduction of fluorine into proteins, nucleic acids, lipids and carbohydrates has allowed mechanistic scrutiny of enzyme catalysis, control of protein oligomerization in membranes, clustered display of ligands on surfaces of living cells, and in increasing the protease stability of protein and peptide therapeutics. (C) 2009 Elsevier B.V. All rights reserved.
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