Journal
JOURNAL OF FLUORESCENCE
Volume 18, Issue 2, Pages 591-597Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10895-007-0303-0
Keywords
nitro-fluorophore; sensor; hypoxic; tumor cell
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Based on the characteristics of a nitro-group, which can be partially or totally reduced to an amino-group in hypoxic cells, two series of hypoxic sensors containing 7H-Benzimidazole [2,1-a]benz[de]isoquinolin-7-one cores with nitro groups in different positions were designed, synthesized and evaluated. The target compounds exhibited significantly different fluorescence characteristics ( fluorescence enhancement or quenching). The strong fluorescences of some partially reduced compounds could be explained through the examination of their infrared spectra, which showed a restriction of the nitro-group vibration. These compounds exhibited significant hypoxic-oxic fluorescence differences not only in numerical values but also in their fluorescent imaging properties as reported for the first time.
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